Building on the previous webinar series, we presented a refresher on the key elements of the estimand framework and use the ETHOS study to illustrate the estimand framework and to highlight the different options that may be of interest to different stakeholders. The background and disease context of the case was described, the important events (termed intercurrent events) occurring in the trial were described and three estimands were showcased. We also explored how best to communicate the estimands in medical journals.
Speakers notably addressed questions on how estimands should be communicated in medical journals and how to encourage their inclusion in journal articles.
Paul Dorinsky (AstraZeneca) and David Wright (AstraZeneca)