Healthcare decision-making is evolving with the integration of Real-World Evidence (RWE). While traditional clinical trials remain crucial, RWE offers valuable insights from everyday clinical practice. This supports the discovery and development of innovative new medicines, helping to understand how medicines work in the real world. RWE complements clinical trial data offering a holistic understanding of treatment effectiveness, safety and value in diverse, real-world populations. The availability of digital health tools, electronic health records (EHRs), and advances in data analytics have enabled the large-scale collection and analysis of Real-World Data (RWD). These developments provide opportunities to bridge the gap between research and routine care.